Propafenone for the treatment of severe ventricular arrhythmias

Twenty-one patients whose severe ventricular arrhythmias were not controlled by other currently used antiarrhythmic agents or who were intolerant of those drugs were treated with a new antiarrhythmic agent, propafenone. This therapy was associated with complete or nearly complete suppression of prem...

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Bibliographic Details
Published in:Canadian Medical Association journal 1984-09, Vol.131 (6), p.601-603
Main Authors: Rabkin, S. W, Rotem, C. E, Boroomand-Rashti, K, Bar-Shlomo, B
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Arrhythmia Agents - adverse effects
Anti-Arrhythmia Agents - pharmacology
Anti-Arrhythmia Agents - therapeutic use
Arrhythmias, Cardiac - drug therapy
Dizziness - chemically induced
Female
Humans
Male
Middle Aged
Nausea - chemically induced
Propafenone
Propiophenones - adverse effects
Propiophenones - therapeutic use
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Summary:Twenty-one patients whose severe ventricular arrhythmias were not controlled by other currently used antiarrhythmic agents or who were intolerant of those drugs were treated with a new antiarrhythmic agent, propafenone. This therapy was associated with complete or nearly complete suppression of premature ventricular beats in 15 (71%) of the patients, satisfactory control in 4 (19%) and no control in 2 (10%). The majority reported no adverse effects. The most frequent complaints were nausea or epigastric discomfort (in five patients) and lightheadedness or dizziness (in three patients). Thus, propafenone appeared to be an effective antiarrhythmic agent with an acceptable frequency of side effects when administered to patients whose ventricular arrhythmias were difficult to treat.
ISSN:0008-4409