Fetal cord blood: aspects of heightened immune responses

Neonatal immune responses have been associated with the development of atopy in childhood. We assessed in cord blood mononuclear cells (CBMC) whether increased allergen/mitogen-induced lymphoproliferation (LP) is associated with pro-allergic Th2 cytokine IL-13 or Th1 cytokine IFN-gamma secretion. We...

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Bibliographic Details
Published in:Journal of clinical immunology 2005-07, Vol.25 (4), p.329-337
Main Authors: Schaub, B, Tantisira, K G, Gibbons, F K, He, H, Litonjua, A A, Gillman, M W, Weiss, S, Perkins, D L, Gold, D R, Finn, P W
Format: Article
Language:English
Subjects:
Adult
Allergens - immunology
Allergens - pharmacology
Cell Proliferation
Cells, Cultured
Dermatophagoides pteronyssinus
Female
Fetal Blood - immunology
Fetal Blood - metabolism
Humans
Immune System - physiology
Interferon-gamma - metabolism
Interleukin-13 - metabolism
Lymphocytes - cytology
Lymphocytes - immunology
Male
Mitogens - pharmacology
Pregnancy
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Summary:Neonatal immune responses have been associated with the development of atopy in childhood. We assessed in cord blood mononuclear cells (CBMC) whether increased allergen/mitogen-induced lymphoproliferation (LP) is associated with pro-allergic Th2 cytokine IL-13 or Th1 cytokine IFN-gamma secretion. We determined whether LP to one allergen is related to heightened lymphocyte function to other allergens/mitogen. CBMC from 135 neonates were stimulated with house dust mite (Derf1), cockroach, ovalbumin, or mitogen. LP to one allergen was associated with significantly increased LP to other allergens/mitogen. Increased Derf1-LP was associated with increased Derf1-induced IL-13 secretion (r = 0.21, p = 0.01). After adjusting for neonatal gender, race, and maternal smoking, Derf1-LP remained associated with Derf1-IL-13 (OR 3.08, 95% CI 1.56-6.10). Increased mitogen-induced proliferation was associated with increased mitogen-induced IL-13 secretion (r = 0.37, p < 0.001). For some individuals, a predisposition to a heightened immune response is already evident at birth. Whether this phenotype results in atopy in childhood warrants further investigation.
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-005-4180-5