An apparent relationship between locoism and lathyrism

An apparent relationship between locoism and lathyrism was investigated. Similarities reported in the literature in botanical relationship, signs produced in affected animals, and chemical characteristics were noted. It was demonstrated that the known lathyrogens, aminoacetonitrile and alpha, gamma-...

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Bibliographic Details
Published in:Canadian journal of comparative medicine and veterinary science 1967-12, Vol.31 (12), p.334-341
Main Authors: Keeler, R F, James, L F, Binns, W, Shupe, J L
Format: Article
Language:English
Subjects:
Abortion, Veterinary - chemically induced
Alanine Transaminase - blood
Aminobutyrates
Animals
Aspartate Aminotransferases - blood
Chromatography, Paper
Cyanides
Female
Fetal Death - chemically induced
Fetal Death - veterinary
Lathyrism - veterinary
Plant Extracts
Plant Poisoning - veterinary
Pregnancy
Sheep
Sheep Diseases - chemically induced
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Summary:An apparent relationship between locoism and lathyrism was investigated. Similarities reported in the literature in botanical relationship, signs produced in affected animals, and chemical characteristics were noted. It was demonstrated that the known lathyrogens, aminoacetonitrile and alpha, gamma-diaminobutyric acid, as well as an extract from the loco plant (expected to contain lathyrogens if present in the plant) produced many of the abortive, teratogenic and neurologic effects and signs evident in animals in true locoism. Preliminary assay of extracts from the plant suggested the presence of lathyrogens in the loco plant.
ISSN:0316-5957