Additive antianginal effect of verapamil in patients receiving propranolol

Ten men with stable angina pectoris not fully relieved by optimal doses of propranolol (mean 218 mg daily) were given a single oral dose of 120 mg verapamil or a placebo on alternate mornings; the order of treatment was double blind. Patients had trained in a protocol that precipitated angina after...

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Bibliographic Details
Published in:BMJ 1982-04, Vol.284 (6322), p.1067-1070
Main Authors: Bassan, Mayer, Weiler-Ravell, Daniel, Shalev, Oded
Format: Article
Language:English
Subjects:
Angina pectoris
Angina Pectoris - drug therapy
Angina Pectoris - physiopathology
Bicycles
Blood pressure
Blood Pressure - drug effects
Clinical Research
Clinical Trials as Topic
Dosage
Double-Blind Method
Drug Therapy, Combination
Exercise
Exercise tolerance
Fatigue
Heart rate
Heart Rate - drug effects
Humans
Physical Exertion
Placebos
Propranolol - therapeutic use
Systolic blood pressure
Time Factors
Verapamil - therapeutic use
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Summary:Ten men with stable angina pectoris not fully relieved by optimal doses of propranolol (mean 218 mg daily) were given a single oral dose of 120 mg verapamil or a placebo on alternate mornings; the order of treatment was double blind. Patients had trained in a protocol that precipitated angina after three to six minutes of exercise on a bicycle ergometer. On test days, and with continued propranolol treatment, bicycle exercise was performed just before the administration of verapamil or placebo and hourly thereafter for eight hours. Mean exercise tolerance was 118 seconds greater one hour after verapamil than one hour after placebo (p
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.284.6322.1067