Growth, development, and reassessment of hypothyroid infants diagnosed by screening

Thirty]six neonates in whom hypothyroidism was diagnosed after thyroid stimulating hormone screening were reassessed at 1 year. All had grown satisfactorily and the mental development scores were normal in all except two. Treatment was withdrawn in 32 and persistent hypothyroidism was confirmed in 3...

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Bibliographic Details
Published in:BMJ 1982-05, Vol.284 (6327), p.1435-1437
Main Authors: Hulse, J A, Grant, D B, Jackson, D, Clayton, B E
Format: Article
Language:English
Subjects:
Bones
Child Development
Children
Congenital Hypothyroidism
Female
Follow-Up Studies
Growth
Hormones
Humans
Hypothyroidism
Hypothyroidism - drug therapy
Hypothyroidism - physiopathology
Infant
Infants
Male
Mass Screening
Neonatal screening
Thyroid function
Thyroid Function Tests
Thyroxine - blood
Thyroxine - therapeutic use
Thyroxine binding proteins
Withdrawal of treatment
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Summary:Thirty]six neonates in whom hypothyroidism was diagnosed after thyroid stimulating hormone screening were reassessed at 1 year. All had grown satisfactorily and the mental development scores were normal in all except two. Treatment was withdrawn in 32 and persistent hypothyroidism was confirmed in 31 cases. Thyroid stimulating hormone concentrations were raised in one-third of cases before the withdrawal of treatment and this was associated with generally lower concentrations of serum thyroxine (T4) and smaller doses of L-thyroxine than in those cases with normal concentrations of thyroid stimulating hormone. In treating congenital hypothyroidism, serum T4 concentrations should be monitored regularly and the dose of thyroxine adjusted to maintain serum T4 in the upper part of the reference range.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.284.6327.1435