Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease

The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricula...

Full description

Saved in:
Bibliographic Details
Published in:BMJ 1982-07, Vol.285 (6338), p.325-327
Main Authors: Taylor, S H, Silke, B, Nelson, G I, Okoli, R C, Ahuja, R C
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - drug effects
Cardiac Output - drug effects
Cardiac output determination
Clinical Research
Coronary artery disease
Coronary Disease - physiopathology
Depressive disorders
Ethanolamines - pharmacology
Heart rate
Hemodynamics
Hemodynamics - drug effects
Humans
Labetalol - pharmacology
Left ventricular function
Male
Middle Aged
Myocardial infarction
Physical Exertion
Propranolol - pharmacology
Pulmonary artery
Random Allocation
Vascular resistance
Vasodilators
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricular function both at rest and during exercise than labetalol. This difference was probably attributable to the vasodilator activity of labetalol and the associated reduction in afterload offsetting the haemodynamic disadvantages of blockade of cardiac beta-adrenoceptors alone. The haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone may thus have therapeutic implications for the use of these treatments in patients with coronary heart disease.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.285.6338.325