Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease

The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricula...

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Published in:BMJ 1982-07, Vol.285 (6338), p.325-327
Main Authors: Taylor, S H, Silke, B, Nelson, G I, Okoli, R C, Ahuja, R C
Format: Article
Language:English
Subjects:
Adult
Blood Pressure - drug effects
Cardiac Output - drug effects
Cardiac output determination
Clinical Research
Coronary artery disease
Coronary Disease - physiopathology
Depressive disorders
Ethanolamines - pharmacology
Heart rate
Hemodynamics
Hemodynamics - drug effects
Humans
Labetalol - pharmacology
Left ventricular function
Male
Middle Aged
Myocardial infarction
Physical Exertion
Propranolol - pharmacology
Pulmonary artery
Random Allocation
Vascular resistance
Vasodilators
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cited_by cdi_FETCH-LOGICAL-b4305-bc094147cf34435cfdef0dea46550fd3e97392835d8f8fff43ce4c51839c73cb3
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container_end_page 327
container_issue 6338
container_start_page 325
container_title BMJ
container_volume 285
creator Taylor, S H
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Nelson, G I
Okoli, R C
Ahuja, R C
description The acute haemodynamic effects of beta-blockade with propranolol and combined alpha-blockade and beta-blockade with labetalol were compared in a randomised study in 12 patients with coronary artery disease proved by angiography. Propranolol induced significantly greater depression of left ventricular function both at rest and during exercise than labetalol. This difference was probably attributable to the vasodilator activity of labetalol and the associated reduction in afterload offsetting the haemodynamic disadvantages of blockade of cardiac beta-adrenoceptors alone. The haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone may thus have therapeutic implications for the use of these treatments in patients with coronary heart disease.
doi_str_mv 10.1136/bmj.285.6338.325
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identifier ISSN: 0007-1447
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source JSTOR Archival Journals and Primary Sources Collection; BMJ_英国医学会期刊; PubMed Central
subjects Adult
Blood Pressure - drug effects
Cardiac Output - drug effects
Cardiac output determination
Clinical Research
Coronary artery disease
Coronary Disease - physiopathology
Depressive disorders
Ethanolamines - pharmacology
Heart rate
Hemodynamics
Hemodynamics - drug effects
Humans
Labetalol - pharmacology
Left ventricular function
Male
Middle Aged
Myocardial infarction
Physical Exertion
Propranolol - pharmacology
Pulmonary artery
Random Allocation
Vascular resistance
Vasodilators
title Haemodynamic advantages of combined alpha-blockade and beta-blockade over beta-blockade alone in patients with coronary heart disease
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