Low-dose Dobutamine Tissue-tagged MRI with 3D Strain Analysis Allows Assessment of Myocardial Viability in Patients with Ischemic Cardiomyopathy

Background: Tissue-tagged magnetic resonance imaging (MRI) with 3-dimensional (3D) myocardial strain analysis allows quantitative assessment of myocardial contractility. We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2006-07, Vol.114 (1 Suppl), p.I33-I36
Main Authors: Bree, Douglas, Wollmuth, Jason R., Cupps, Brian P., Krock, Marc D., Howells, Analyn, Moazami, Nader, Pasque, Michael K., Rogers, Joseph
Format: Article
Language:English
Online Access:Get full text
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Summary:Background: Tissue-tagged magnetic resonance imaging (MRI) with 3-dimensional (3D) myocardial strain analysis allows quantitative assessment of myocardial contractility. We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM). Methods: MRI with radiofrequency tissue-tagging at rest and with low-dose dobutamine was performed in 16 normal volunteers and 14 patients with ICM. Three-dimensional global and regional circumferential strains (Ecc) were computed for all subjects at rest and with dobutamine. Results were compared to clinically indicated conventional viability studies. Results: Compared to normal volunteers, global left ventricular Ecc was significantly decreased in patients with ICM at rest (−0.15 ± 0.06 vs. −0.27 ± 0.03, p
ISSN:0009-7322
1524-4539
DOI:10.1161/CIRCULATIONAHA.105.000885