Low-dose Dobutamine Tissue-tagged MRI with 3D Strain Analysis Allows Assessment of Myocardial Viability in Patients with Ischemic Cardiomyopathy

Background: Tissue-tagged magnetic resonance imaging (MRI) with 3-dimensional (3D) myocardial strain analysis allows quantitative assessment of myocardial contractility. We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and...

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Published in:Circulation (New York, N.Y.) N.Y.), 2006-07, Vol.114 (1 Suppl), p.I33-I36
Main Authors: Bree, Douglas, Wollmuth, Jason R., Cupps, Brian P., Krock, Marc D., Howells, Analyn, Moazami, Nader, Pasque, Michael K., Rogers, Joseph
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container_issue 1 Suppl
container_start_page I33
container_title Circulation (New York, N.Y.)
container_volume 114
creator Bree, Douglas
Wollmuth, Jason R.
Cupps, Brian P.
Krock, Marc D.
Howells, Analyn
Moazami, Nader
Pasque, Michael K.
Rogers, Joseph
description Background: Tissue-tagged magnetic resonance imaging (MRI) with 3-dimensional (3D) myocardial strain analysis allows quantitative assessment of myocardial contractility. We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM). Methods: MRI with radiofrequency tissue-tagging at rest and with low-dose dobutamine was performed in 16 normal volunteers and 14 patients with ICM. Three-dimensional global and regional circumferential strains (Ecc) were computed for all subjects at rest and with dobutamine. Results were compared to clinically indicated conventional viability studies. Results: Compared to normal volunteers, global left ventricular Ecc was significantly decreased in patients with ICM at rest (−0.15 ± 0.06 vs. −0.27 ± 0.03, p
doi_str_mv 10.1161/CIRCULATIONAHA.105.000885
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We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM). Methods: MRI with radiofrequency tissue-tagging at rest and with low-dose dobutamine was performed in 16 normal volunteers and 14 patients with ICM. Three-dimensional global and regional circumferential strains (Ecc) were computed for all subjects at rest and with dobutamine. Results were compared to clinically indicated conventional viability studies. Results: Compared to normal volunteers, global left ventricular Ecc was significantly decreased in patients with ICM at rest (−0.15 ± 0.06 vs. −0.27 ± 0.03, p&lt;0.001) and with dobutamine (−0.17 ± 0.08 vs. −0.37 ± 0.10, p&lt;0.001). Ecc was significantly decreased in nonviable regions compared to viable segments at rest (−0.08 ± 0.06 vs. −0.17 ± 0.10, p&lt;0.001) and with dobutamine (−0.07 ± 0.06 vs. −0.21 ± 0.11, p&lt;0.001). Ecc in viable segments increased significantly in response to dobutamine (p=0.04) whereas Ecc did not change in nonviable segments (p=0.50). Normal controls (96 segments) had increased Ecc at rest (−0.27 ± 0.07) and with dobutamine (−0.37 ± 0.15) compared to both viable and nonviable regions in ICM patients (p&lt;0.001). Conclusions: Noninvasive dobutamine tissue-tagged MRI with calculation of 3D strain allows the identification, quantification and display of regionally varying ventricular function. The response of systolic strain to low-dose dobutamine has significant promise in discriminating between viable and nonviable myocardium.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/CIRCULATIONAHA.105.000885</identifier><identifier>PMID: 16820595</identifier><language>eng</language><ispartof>Circulation (New York, N.Y.), 2006-07, Vol.114 (1 Suppl), p.I33-I36</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Bree, Douglas</creatorcontrib><creatorcontrib>Wollmuth, Jason R.</creatorcontrib><creatorcontrib>Cupps, Brian P.</creatorcontrib><creatorcontrib>Krock, Marc D.</creatorcontrib><creatorcontrib>Howells, Analyn</creatorcontrib><creatorcontrib>Moazami, Nader</creatorcontrib><creatorcontrib>Pasque, Michael K.</creatorcontrib><creatorcontrib>Rogers, Joseph</creatorcontrib><title>Low-dose Dobutamine Tissue-tagged MRI with 3D Strain Analysis Allows Assessment of Myocardial Viability in Patients with Ischemic Cardiomyopathy</title><title>Circulation (New York, N.Y.)</title><description>Background: Tissue-tagged magnetic resonance imaging (MRI) with 3-dimensional (3D) myocardial strain analysis allows quantitative assessment of myocardial contractility. We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM). Methods: MRI with radiofrequency tissue-tagging at rest and with low-dose dobutamine was performed in 16 normal volunteers and 14 patients with ICM. Three-dimensional global and regional circumferential strains (Ecc) were computed for all subjects at rest and with dobutamine. Results were compared to clinically indicated conventional viability studies. Results: Compared to normal volunteers, global left ventricular Ecc was significantly decreased in patients with ICM at rest (−0.15 ± 0.06 vs. −0.27 ± 0.03, p&lt;0.001) and with dobutamine (−0.17 ± 0.08 vs. −0.37 ± 0.10, p&lt;0.001). Ecc was significantly decreased in nonviable regions compared to viable segments at rest (−0.08 ± 0.06 vs. −0.17 ± 0.10, p&lt;0.001) and with dobutamine (−0.07 ± 0.06 vs. −0.21 ± 0.11, p&lt;0.001). Ecc in viable segments increased significantly in response to dobutamine (p=0.04) whereas Ecc did not change in nonviable segments (p=0.50). Normal controls (96 segments) had increased Ecc at rest (−0.27 ± 0.07) and with dobutamine (−0.37 ± 0.15) compared to both viable and nonviable regions in ICM patients (p&lt;0.001). Conclusions: Noninvasive dobutamine tissue-tagged MRI with calculation of 3D strain allows the identification, quantification and display of regionally varying ventricular function. 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We assessed the hypothesis that 3D strain determination at rest and with low-dose dobutamine would discriminate between viable and nonviable myocardium in patients with ischemic cardiomyopathy (ICM). Methods: MRI with radiofrequency tissue-tagging at rest and with low-dose dobutamine was performed in 16 normal volunteers and 14 patients with ICM. Three-dimensional global and regional circumferential strains (Ecc) were computed for all subjects at rest and with dobutamine. Results were compared to clinically indicated conventional viability studies. Results: Compared to normal volunteers, global left ventricular Ecc was significantly decreased in patients with ICM at rest (−0.15 ± 0.06 vs. −0.27 ± 0.03, p&lt;0.001) and with dobutamine (−0.17 ± 0.08 vs. −0.37 ± 0.10, p&lt;0.001). Ecc was significantly decreased in nonviable regions compared to viable segments at rest (−0.08 ± 0.06 vs. −0.17 ± 0.10, p&lt;0.001) and with dobutamine (−0.07 ± 0.06 vs. −0.21 ± 0.11, p&lt;0.001). Ecc in viable segments increased significantly in response to dobutamine (p=0.04) whereas Ecc did not change in nonviable segments (p=0.50). Normal controls (96 segments) had increased Ecc at rest (−0.27 ± 0.07) and with dobutamine (−0.37 ± 0.15) compared to both viable and nonviable regions in ICM patients (p&lt;0.001). Conclusions: Noninvasive dobutamine tissue-tagged MRI with calculation of 3D strain allows the identification, quantification and display of regionally varying ventricular function. The response of systolic strain to low-dose dobutamine has significant promise in discriminating between viable and nonviable myocardium.</abstract><pmid>16820595</pmid><doi>10.1161/CIRCULATIONAHA.105.000885</doi></addata></record>
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title Low-dose Dobutamine Tissue-tagged MRI with 3D Strain Analysis Allows Assessment of Myocardial Viability in Patients with Ischemic Cardiomyopathy
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