A crossover comparison of extended release felodipine with prolonged action nifedipine in hypertension

In a crossover design, control of blood pressure by extended release felodipine was compared with control by prolonged action nifedipine in 21 children with renal hypertension. Compliance with once daily felodipine was higher than with nifedipine, at 95.6 (SEM 2.7)% v 78.9 (6.0)% (p = 0.02). Mean di...

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Bibliographic Details
Published in:Archives of disease in childhood 1995-08, Vol.73 (2), p.154-156
Main Authors: Moncica, I, Oh, P I, ul Qamar, I, Scolnik, D, Arbus, G S, Hebert, D, Balfe, J W, Koren, G
Format: Article
Language:English
Subjects:
Adolescent
Antihypertensive agents
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Blood pressure
Cardiovascular system
Child
Cross-Over Studies
Delayed-Action Preparations
Drug Administration Schedule
Felodipine
Felodipine - therapeutic use
Humans
Hypertension
Hypertension, Renal - drug therapy
Medical sciences
Nifedipine
Nifedipine - therapeutic use
Patient Compliance
Pediatrics
Pharmacology. Drug treatments
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Summary:In a crossover design, control of blood pressure by extended release felodipine was compared with control by prolonged action nifedipine in 21 children with renal hypertension. Compliance with once daily felodipine was higher than with nifedipine, at 95.6 (SEM 2.7)% v 78.9 (6.0)% (p = 0.02). Mean diastolic blood pressure was lower during the day with felodipine than with nifedipine, at 77.6 (2.4) v 84.4 (2.8) mm Hg (p = 0.05). Similarly, blood pressure load (the percentage of the day during which the child had blood pressure exceeding the upper limits of normal for age) was lower for felodipine than for nifedipine: 43.5 (5.5)% v 61.3 (6.3)%. There was an opposite trend during the night, though this did not reach statistical significance. These data suggest that once a day felodipine is effective in children with hypertension. This may be because of improved compliance.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.73.2.154