Effect of prolonged hyperdynamic endotoxemia on jejunal motility in fasted and enterally fed pigs

To determine the effects of hyperdynamic endotoxemia on the motility of the small intestine. Motility disorders of the gastrointestinal tract are a common complication of sepsis. It has been suggested that gram-negative endotoxin plays a role in the pathogenesis of the accompanying diarrhea frequent...

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Bibliographic Details
Published in:Annals of surgery 2003, Vol.237 (1), p.44-51
Main Authors: BRUINS, Maaike J, LUIKING, Yvette C, SOETERS, Peter B, AKKERMANS, Louis M. A, DEUTZ, Nicolaas E. P
Format: Article
Language:English
Subjects:
Animals
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Blood Flow Velocity
Disease Models, Animal
Endotoxemia - physiopathology
Endotoxins - pharmacology
Enteral Nutrition
Fasting
Female
Gastrointestinal Motility - drug effects
Gastrointestinal Motility - physiology
Gastrointestinal Transit - drug effects
Gastrointestinal Transit - physiology
Human bacterial diseases
Infectious diseases
Jejunum - drug effects
Jejunum - physiopathology
Manometry
Medical sciences
Myoelectric Complex, Migrating - drug effects
Original
Reference Values
Swine
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Summary:To determine the effects of hyperdynamic endotoxemia on the motility of the small intestine. Motility disorders of the gastrointestinal tract are a common complication of sepsis. It has been suggested that gram-negative endotoxin plays a role in the pathogenesis of the accompanying diarrhea frequently observed. Pigs were infused with lipopolysaccharide for a 24-hour period. During this fasting period jejunal motility was measured using ambulatory manometry. One and 4 days after cessation of endotoxin, pigs were enterally fed, and again motility was recorded. Hyperdynamic endotoxemia was achieved in this model. Manometric pressure recordings revealed that endotoxin infusion accelerated the migrating motor complex (MMC) migration along the jejunum. Also, a simultaneous increase in MMC cycling frequency was observed in the endotoxin-treated group. Elevated MMC migration velocity and cycling frequency were maintained the following day after endotoxin during feeding and returned to basal values 4 days after endotoxin. A small dose of continuously infused endotoxin significantly provokes jejunal motility disturbances that may contribute to diarrhea.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-200301000-00007