EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the...

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Bibliographic Details
Published in:The Journal of clinical investigation 2003-04, Vol.111 (8), p.1125-1132
Main Authors: Teramoto, Tetsuyuki, Qiu, Jianhua, Plumier, Jean-Christophe, Moskowitz, Michael A
Format: Article
Language:English
Subjects:
Anatomie (cytologie, histologie, embryologie...) & physiologie
Anatomy (cytology, histology, embryology...) & physiology
Animals
Antibodies
Biomedical research
Biotechnology
Brain Ischemia - drug therapy
Brain Ischemia - pathology
Brain Ischemia - physiopathology
Brain Ischemia/drug therapy/pathology/physiopathology
Cell Differentiation - drug effects
Cell Division - drug effects
Corpus Striatum - drug effects
Dopamine and cAMP-Regulated Phosphoprotein 32
Epidermal growth factor
Epidermal Growth Factor - pharmacology
Epidermal Growth Factor - therapeutic use
Epidermal Growth Factor/pharmacology/therapeutic use
Interneurons - drug effects
Ischemia
Laboratory animals
Life sciences
Male
Mice
Nerve Tissue Proteins
Neurogenesis
Neurons - drug effects
Neurons - physiology
Neurons/drug effects/physiology
Parvalbumins - analysis
Phenotype
Phosphoproteins - analysis
Sciences du vivant
Stem cells
Traumatic brain injury
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Summary:EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair.
ISSN:0021-9738
1558-8238
1558-8238
DOI:10.1172/JCI200317170