Multifunctional effects of anticomplementary agent K‐76 on carrageenan‐induced colitis in the rabbit

SUMMARY In this study the effect of K‐76. a sesquiterpcne compound with anticomplementary activity isolated from a fungus culture, on carrageenan‐induced colitis was studied from biochemical, histological and immunohistopathological aspects. K‐76 suppressed epithelial cell loss, crypt abscess format...

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Bibliographic Details
Published in:Clinical and experimental immunology 1993-11, Vol.94 (2), p.348-353
Main Authors: KITANO, A., MATSUMOTO, T., NAKAMURA, S., OSHITANI, N., OBATA, A., OKAWA, K., INOUE, Y., KOBAYASHI, K., NAKURA, H.
Format: Article
Language:English
Subjects:
Animals
anticomplement
Biological and medical sciences
Carrageenan - toxicity
carrageenan‐induced colitis sesquiterpene
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - immunology
Complement C3 - metabolism
Complement Hemolytic Activity Assay
Complement Inactivator Proteins - pharmacokinetics
Complement Inactivator Proteins - pharmacology
Disease Models, Animal
Drug toxicity and drugs side effects treatment
Immunoglobulin G - metabolism
Immunoglobulin M - metabolism
Immunohistochemistry
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Mucoproteins - blood
Pharmacology. Drug treatments
rabbit
Rabbits
Sesquiterpenes - blood
Sesquiterpenes - pharmacology
ulcerative colitis
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Summary:SUMMARY In this study the effect of K‐76. a sesquiterpcne compound with anticomplementary activity isolated from a fungus culture, on carrageenan‐induced colitis was studied from biochemical, histological and immunohistopathological aspects. K‐76 suppressed epithelial cell loss, crypt abscess formation, inflammatory cell infiltration, mucosal atrophy, and ulceration. Immunohistochcmical examination ofthe colonic mucosa showed that the number of IgG‐ and IgM‐positive plasma cells and the staining intensity for IgG and C3 were increased in carrageenan‐induced colitis, but these changes were inhibited by K‐76. Besides, serum mucoprotcin concentrations and CH50 levels were lower in the animals treated with carrageenan alone. K‐76 exerted multifunctional activity, although its mechanisms of action remain obscure.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1993.tb03456.x