Increased proportion of responders to a murine anti‐CD3 monoclonal antibody of the IgG1 class in patients with systemic lupus erythematosus (SLE)

A group of Venezuelan patients with SLE showed an increased proportion of responders to Leu-4, an anti-CD3 MoAb of the IgG1 class, compared with ethnically matched non-SLE patients and healthy controls. The rate of proliferative responses or IL-2 production induced by MoAb Leu-4, and the helper effe...

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Bibliographic Details
Published in:Clinical and experimental immunology 1993-12, Vol.94 (3), p.423-428
Main Authors: BLASINI, A. M, STEKMAN, I. L, LEON-PONTE, M, CLADERA, D, RODRIGUEZ, M. A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antibodies, Monoclonal - immunology
Biological and medical sciences
CD3 Complex - immunology
Female
Humans
Immunoglobulin G - classification
Immunoglobulin G - immunology
Interleukin-2 - biosynthesis
Lupus Erythematosus, Systemic - immunology
Lymphocyte Activation
Macrophages - immunology
Male
Medical sciences
Mice
Monocytes - immunology
Receptors, Fc - biosynthesis
Receptors, IgG - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
T-Lymphocytes - immunology
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Summary:A group of Venezuelan patients with SLE showed an increased proportion of responders to Leu-4, an anti-CD3 MoAb of the IgG1 class, compared with ethnically matched non-SLE patients and healthy controls. The rate of proliferative responses or IL-2 production induced by MoAb Leu-4, and the helper effect of macrophages from Leu-4 responders on T cells from a third-party donor were comparable in patients and controls. No significant differences in the binding of murine IgG1 molecules by macrophages from SLE patients and controls were observed. The proportion of monocytes/macrophages expressing Fc gamma RI was significantly higher in SLE patients. However, the expression of FcRII, the type capable of supporting Leu-4-mediated responses, and of Fc gamma RIII was comparable in monocytes from SLE patients and controls. Our results suggest that Venezuelan patients with SLE may have a genetic predisposition for the expression of the phenotypic variant of Fc gamma RII capable of binding murine IgG1 molecules.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1993.tb08212.x