IgA Polyspecific autoantibodies in IgA nephropathy

SUMMARY The specificity of circulating and kidney‐bound IgA during IgA nephropathy is suit a matter of discussion. In the present study, high levels of IgA antibodies directed against a panel of self and non‐out of the seven kidney biopsies studied. After immunoedsorption of pooled selected serum sa...

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Bibliographic Details
Published in:Clinical and experimental immunology 1990-03, Vol.79 (3), p.361-366
Main Authors: MATSIOTA, P., DOSQUET, P., LOUZIR, H., DRUET, E., DRUET, P., AVRAMEAS, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibody Specificity
Autoantibodies - analysis
Biological and medical sciences
Female
Glomerulonephritis
Glomerulonephritis, IGA - immunology
Humans
IgA nephropathy
Immunoglobulin A - analysis
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
polyspecific antibodies
renal eluates
serum
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Summary:SUMMARY The specificity of circulating and kidney‐bound IgA during IgA nephropathy is suit a matter of discussion. In the present study, high levels of IgA antibodies directed against a panel of self and non‐out of the seven kidney biopsies studied. After immunoedsorption of pooled selected serum samples on TNP and getin‐coated columns, polyspecific IgA antibodies were elated. This supports the hypothesis that IgA‐bearing B cells clones most probably producing polyspecific antibodies are a major feature of human IgA nephropathy. These findings also suggest that it may be hazardous to draw conclusions from the findings of apparent monospecific IgA antibodies in this condition.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1990.tb08096.x