Selective deficiency of interferon‐gamma production in the hyper‐IgE syndrome. Relationship to in vitro IgE synthesis

We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. The biosynthesis of IFN-gamma was severely reduced or undetectable in HIgE, while it was near normal in most atopic patients. The...

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Bibliographic Details
Published in:Clinical and experimental immunology 1991-04, Vol.84 (1), p.28-33
Main Authors: PAGANELLI, R, SCALA, E, CAPOBIANCHI, M. R, FANALES-BELASIO, E, D'OFFIZI, G, FIORILLI, M, AIUTI, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Calcimycin - pharmacology
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Hypergammaglobulinemia - immunology
Hypergammaglobulinemia - metabolism
Hypersensitivity, Immediate - immunology
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin E - biosynthesis
Immunoglobulin E - metabolism
Immunoglobulinopathies
Immunopathology
Interferon-gamma - biosynthesis
Interleukin-4 - pharmacology
Lymphocyte Activation - immunology
Male
Medical sciences
Middle Aged
Mitogens - pharmacology
Recombinant Proteins
Syndrome
Tetradecanoylphorbol Acetate - pharmacology
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Summary:We measured the in vitro production of interferon-gamma (IFN-gamma) in five cases of hyper-IgE syndrome (HIgE), induced by mitogens, calcium ionophores and phorbol ester. The biosynthesis of IFN-gamma was severely reduced or undetectable in HIgE, while it was near normal in most atopic patients. The in vitro spontaneous production of IgE was increased overall in HIgE patients, although no correlation was found with serum IgE levels. Recombinant interleukin-4 (IL-4) induced a further increase in IgE synthesis, and its effect was totally antagonized by recombinant IFN-gamma; the same pattern of response was also observed in atopic subjects with high production of IgE. IFN-alpha synergized with IL-4 on IgE synthesis, whereas recombinant IL-6 gave opposite changes in individual cases tested. We propose that IFN-gamma deficiency may be responsible for some of the features of HIgE patients, including IgE levels and infections.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1991.tb08119.x