Chronic serum sickness in the rat: influence of antigen dose, route of antigen administration and strain of rat on the development of disease

Chronic serum sickness (CSS) with systemic immune complex deposition has been produced in female Fischer (F344) rats by the daily intravenous (i.v.) administration of 2.0 mg bovine serum albumin (BSA) (Arisz et al., 1979). In the experiments described below, daily i.v. doses ranging from 0.5 to 10.0...

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Bibliographic Details
Published in:Clinical and experimental immunology 1981-12, Vol.46 (3), p.499-507
Main Authors: Noble, B, Milgrom, M, Van Liew, J B, Brentjens, J R
Format: Article
Language:English
Subjects:
Animals
Antigen-Antibody Complex - analysis
Antigens - administration & dosage
Chronic Disease
Disease Models, Animal
Female
Glomerulonephritis - immunology
Immune Complex Diseases - immunology
Injections, Intraperitoneal
Injections, Intravenous
Rats
Rats, Inbred F344
Rats, Inbred Strains
Serum Albumin, Bovine - administration & dosage
Serum Albumin, Bovine - immunology
Serum Sickness - immunology
Species Specificity
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Summary:Chronic serum sickness (CSS) with systemic immune complex deposition has been produced in female Fischer (F344) rats by the daily intravenous (i.v.) administration of 2.0 mg bovine serum albumin (BSA) (Arisz et al., 1979). In the experiments described below, daily i.v. doses ranging from 0.5 to 10.0 mg BSA were found to be effective in producing CSS in F344 strain rats. The severity of renal disease and the extent of extrarenal immune complex deposition were increased with higher daily doses of BSA. Daily administration of different doses of BSA by an intraperitoneal (i.p.) route resulted only in slight mesangial glomerular abnormalities and did not cause abnormal elevation of urinary protein excretion. At the same time, extrarenal accumulation of immune deposits similar to that observed in rats given BSA by the i.v. route was seen. Wistar and Lewis (LEW) strain rats were similar to F344 strain rats in susceptibility to the induction of CSS, but daily i.v. injection of 2.0 mg BSA failed to produce the disease in Brown Norway (BN) rats. The latter observation suggests that genetic differences may influence the expression of immune complex disease in this model.
ISSN:0009-9104
1365-2249