Antibody production and antigenic specific suppression to bovine serum albumin in uremic rats

Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 1982-04, Vol.48 (1), p.111-117
Main Authors: Mezzano, S, Pesce, A, Peters, Jr, T, Pollak, V E, Reed, R, Michael, G
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Cattle
Epitopes
Immunization, Secondary
Immunosuppression
Male
Peptide Fragments - blood
Peptide Fragments - immunology
Rats
Rats, Inbred Strains
Serum Albumin, Bovine - immunology
Serum Albumin, Bovine - metabolism
Uremia - etiology
Uremia - immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antibody response and antigen specific suppression to bovine serum albumin (BSA) in uremic rats have been investigated. Primary immune response was found to be significantly reduced independent of the route of administration or adjuvant while secondary response was affected only in animals in which a weak adjuvant such as Al(OH)3 was used. Antigen specific suppression of uremic rats was achieved by intravenous pretreatment with BSA or a C terminal fragment (505-582) of BSA. Secondary response in sham operated controls was suppressed by BSA but not by the fragment. There was about five-fold greater retention of the fragments in the uremic rats than in sham-operated controls at a 6 hr or later after i.v. administration.
ISSN:0009-9104
1365-2249