Effect of red cell transfusions, thymic hormone and deoxycytidine in severe combined immunodeficiency due to adenosine deaminase deficiency

A child with severe combined immunodeficiency due to adenosine deaminase deficiency was treated with thymic hormone (TP1) alone, thymic hormone with red cell transfusions and finally with a combination of these and parenteral deoxycytidine. TP1 alone produced no benefit while the addition of red cel...

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Bibliographic Details
Published in:Clinical and experimental immunology 1982-11, Vol.50 (2), p.303-310
Main Authors: Davies, E G, Levinsky, R J, Webster, D R, Simmonds, H A, Perrett, D
Format: Article
Language:English
Subjects:
Adenosine Deaminase - deficiency
Adenosine Triphosphate - blood
Blood Transfusion
Deoxyadenine Nucleotides - blood
Deoxyadenosines - metabolism
Deoxycytidine - therapeutic use
Erythrocyte Transfusion
Humans
Immunologic Deficiency Syndromes - etiology
Immunologic Deficiency Syndromes - therapy
Infant, Newborn
Leukocyte Count
Male
Nucleoside Deaminases - deficiency
T-Lymphocytes - immunology
Thymus Extracts - therapeutic use
Tissue Extracts - therapeutic use
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Summary:A child with severe combined immunodeficiency due to adenosine deaminase deficiency was treated with thymic hormone (TP1) alone, thymic hormone with red cell transfusions and finally with a combination of these and parenteral deoxycytidine. TP1 alone produced no benefit while the addition of red cell transfusions resulted in only partial immunological restoration despite improvement in clinical and biochemical findings. Deoxycytidine given subcutaneously produced no additional benefit in any of the parameters measured.
ISSN:0009-9104
1365-2249