Anti-spectrin in sera containing smooth muscle autoantibodies from patients with chronic active hepatitis

Sera from patients with chronic active hepatitis containing anti-smooth muscle autoantibodies (SMA) react against rabbit muscle actin as well as human red cell spectrin. These anti-spectrin antibodies recognize the same antigen as rabbit anti-human spectrin antibodies and are not involved in the sta...

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Bibliographic Details
Published in:Clinical and experimental immunology 1981-01, Vol.43 (1), p.87-93
Main Authors: Garbarz, M, Dhermy, D, Bournier, O, Bezeaud, A, Boivin, P
Format: Article
Language:English
Subjects:
Actins - immunology
Autoantibodies - analysis
Chronic Disease
Electrophoresis, Polyacrylamide Gel
Hepatitis - immunology
Humans
Immunodiffusion
Membrane Proteins - immunology
Muscle, Smooth - immunology
Spectrin - immunology
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Summary:Sera from patients with chronic active hepatitis containing anti-smooth muscle autoantibodies (SMA) react against rabbit muscle actin as well as human red cell spectrin. These anti-spectrin antibodies recognize the same antigen as rabbit anti-human spectrin antibodies and are not involved in the staining pattern given by SMA-containing sera tested with smooth muscle sections. These anti-spectrin antibodies probably recognize an antigenic structure common to both spectrin and another as yet undetermined molecule (which however is not likely to be myosin).
ISSN:0009-9104
1365-2249