The effects of defibrination with ancrod in experimental allergic glomerular injury

Quantitative studies of the effects of defibrination (with ancrod) have been undertaken in two forms of allergic glomerular damage, nephrotoxic serum nephritis and acute serum sickness in rabbits. No differences in intrarenal fixation of nephrotoxic antibody, complement activation or host antibody r...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 1975-05, Vol.20 (2), p.303-309
Main Authors: Naish, P F, Evans, D J, Peters, D K
Format: Article
Language:English
Subjects:
Ancrod - therapeutic use
Animals
Antibodies
Antigen-Antibody Complex
Basement Membrane - immunology
Disease Models, Animal
Endopeptidases - therapeutic use
Fibrin - analysis
Immunoglobulin G
Kidney Glomerulus - immunology
Male
Nephritis - drug therapy
Nephritis - immunology
Proteinuria - immunology
Rabbits
Serum Albumin, Bovine
Serum Sickness - drug therapy
Urea - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Quantitative studies of the effects of defibrination (with ancrod) have been undertaken in two forms of allergic glomerular damage, nephrotoxic serum nephritis and acute serum sickness in rabbits. No differences in intrarenal fixation of nephrotoxic antibody, complement activation or host antibody response were detected between defibrinated and untreated rabbits with nephrotoxic serum nephritis. Defibrination prevented intraglomerular fibrin deposition in this disease; but some glomerular damage as shown by a rise in blood urea and endothelial proliferation still occurred in defibrinated animals. No differences in immune elimination of BSA, circulating immune complex formation or intrarenal localization of immune complexes were noted in defibrinated animals with acute serum sickness. No intraglomerular fibrin deposition was detected in treated or untreated animals in this disease model. It is concluded that the protective effects of ancrod are directly related to defibrination, and not to any other modification of allergic events.
ISSN:0009-9104
1365-2249