The role of C3 in the autologous phase of nephrotoxic nephritis

The role of complement has been studied in the autologous phase of nephrotoxic nephritis (NTN) in rabbits. No reduction in glomerular fibrin deposition, crescent formation or protection from renal failure was observed in either the standard model of NTN when decomplementing doses of cobra venom fact...

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Bibliographic Details
Published in:Clinical and experimental immunology 1976-06, Vol.24 (3), p.464-473
Main Authors: Thomson, N M, Naish, P F, Simpson, I J, Peters, D K
Format: Article
Language:English
Subjects:
Animals
Antibodies - analysis
Basement Membrane - immunology
Blood Coagulation Tests
Cell Division - drug effects
Complement C3 - analysis
Complement C3 - physiology
Complement System Proteins - physiology
Creatinine - blood
Fibrin - analysis
Immunoglobulin G - analysis
Kidney Glomerulus - immunology
Leukocyte Count
Leukocytes - immunology
Male
Nephritis - immunology
Proteinuria
Rabbits
Snake Venoms - pharmacology
Time Factors
Urea - blood
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Summary:The role of complement has been studied in the autologous phase of nephrotoxic nephritis (NTN) in rabbits. No reduction in glomerular fibrin deposition, crescent formation or protection from renal failure was observed in either the standard model of NTN when decomplementing doses of cobra venom factor (CVF) were given before the autologous phase or in a telescoped model when CVF was administered before the nephrotoxic antibody. In the latter situation glomerular fibrin deposition and crescent formation were found in the absence of detectable deposition of C3. However, substantial protection was observed when circulating polymorphonuclear leucocytes (PMN) were depleted by antipolymorph serum. These observations establish the existence of a system of allergic glomerular injury mediated by PMN but independent of C3. It is postulated that this system may account for the glomerular injury seen in patients with Goodpasture's syndrome in whom glomerular C3 deposition is not found.
ISSN:0009-9104
1365-2249