C3b receptors in glomerular disease

Using two indicator systems--sheep erythrocytes or fluoresceinated S. typhi coated with C3b the presence of a receptor for C3b (but not C3d) in the normal human glomerulus is confirmed. No receptor could be detected in other species tested (mouse, rat, guinea-pig, rabbit and rhesus monkey). Binding...

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Bibliographic Details
Published in:Clinical and experimental immunology 1977-05, Vol.28 (2), p.212-217
Main Authors: Moran, J, Colasanti, G, Amos, N, Peters, D K
Format: Article
Language:English
Subjects:
Animals
Binding Sites, Antibody
Complement C3 - antagonists & inhibitors
Complement C3 - metabolism
Complement System Proteins - metabolism
Guinea Pigs
Haplorhini
Humans
Kidney Diseases - immunology
Kidney Glomerulus - immunology
Macaca mulatta
Mice
Rabbits
Rats
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Summary:Using two indicator systems--sheep erythrocytes or fluoresceinated S. typhi coated with C3b the presence of a receptor for C3b (but not C3d) in the normal human glomerulus is confirmed. No receptor could be detected in other species tested (mouse, rat, guinea-pig, rabbit and rhesus monkey). Binding of indicator particles was reduced or lost in diseases associated with glomerular capillary deposition of C3, but not in those with mesangial deposition alone. However in some cases the receptor was lost in the absence of detectable C3 deposition. No receptors were detected in proliferating cells in glomerular crescents.
ISSN:0009-9104
1365-2249