Epitope specificity of spontaneous and induced thyroglobulin autoantibodies in the rat

We have investigated the epitope specificities of rat thyroglobulin (Tg) autoantibodies arising either spontaneously in BB hybrid and BB rats or following induction in normal rats with thyroglobulin and adjuvant. Using a panel of thyroglobulins from different animal species it was possible to identi...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 1988-10, Vol.74 (1), p.63-67
Main Authors: DE ASSIS-PAIVA, H. J, CHAMPION, B, RAYNER, D. C, COLLE, E, BONE, A, ROITT, I. M, COOKE, A
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - biosynthesis
Binding, Competitive
Biological and medical sciences
Cross Reactions
Dogs
Epitopes - analysis
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Mice
Rats
Rats, Inbred BB
Species Specificity
Thyroglobulin - immunology
Thyroxine - immunology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have investigated the epitope specificities of rat thyroglobulin (Tg) autoantibodies arising either spontaneously in BB hybrid and BB rats or following induction in normal rats with thyroglobulin and adjuvant. Using a panel of thyroglobulins from different animal species it was possible to identify three different patterns of reactivity. These were: 1) recognition of all species of thyroglobulin; (2) recognition restricted to rat and mouse thyroglobulins and 3) recognition biased towards dog, rat and mouse thyroglobulins. Furthermore, using human thyroglobulin manifesting different levels of iodination, it was possible to show that sera with recognition pattern 1 recognized the iodination site of thyroglobulin and that this was inhibitable by thyroxine. Taken together these data provide evidence of restricted epitope recognition by Tg autoantibodies in the rat.
ISSN:0009-9104
1365-2249