Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction

We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-depend...

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Bibliographic Details
Published in:Clinical and experimental immunology 1989, Vol.75 (1), p.106-112
Main Authors: DE ASSIS-PAIVA, H. J, RAYNER, D. C, ROITT, I. M, COOKE, A
Format: Article
Language:English
Subjects:
Animals
Autoantibodies - biosynthesis
Biological and medical sciences
Dose-Response Relationship, Immunologic
Endocrinopathies
Female
Fluorescent Antibody Technique
Freund's Adjuvant
Haplotypes
Histocompatibility Antigens Class II - genetics
Leukocyte Count
Macrophages - immunology
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Phenotype
Rats
Rats, Inbred Strains
T-Lymphocytes - immunology
Thyroglobulin - immunology
Thyroid Gland - pathology
Thyroid. Thyroid axis (diseases)
Thyroiditis, Autoimmune - genetics
Thyroiditis, Autoimmune - immunology
Thyroiditis, Autoimmune - pathology
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Summary:We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate.
ISSN:0009-9104
1365-2249