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Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction
We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-depend...
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| Published in: | Clinical and experimental immunology 1989, Vol.75 (1), p.106-112 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 112 |
| container_issue | 1 |
| container_start_page | 106 |
| container_title | Clinical and experimental immunology |
| container_volume | 75 |
| creator | DE ASSIS-PAIVA, H. J RAYNER, D. C ROITT, I. M COOKE, A |
| description | We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate. |
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J ; RAYNER, D. C ; ROITT, I. M ; COOKE, A</creator><creatorcontrib>DE ASSIS-PAIVA, H. J ; RAYNER, D. C ; ROITT, I. M ; COOKE, A</creatorcontrib><description>We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>PMID: 2649281</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Autoantibodies - biosynthesis ; Biological and medical sciences ; Dose-Response Relationship, Immunologic ; Endocrinopathies ; Female ; Fluorescent Antibody Technique ; Freund's Adjuvant ; Haplotypes ; Histocompatibility Antigens Class II - genetics ; Leukocyte Count ; Macrophages - immunology ; Medical sciences ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Phenotype ; Rats ; Rats, Inbred Strains ; T-Lymphocytes - immunology ; Thyroglobulin - immunology ; Thyroid Gland - pathology ; Thyroid. Thyroid axis (diseases) ; Thyroiditis, Autoimmune - genetics ; Thyroiditis, Autoimmune - immunology ; Thyroiditis, Autoimmune - pathology</subject><ispartof>Clinical and experimental immunology, 1989, Vol.75 (1), p.106-112</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541870/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541870/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7213709$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2649281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE ASSIS-PAIVA, H. J</creatorcontrib><creatorcontrib>RAYNER, D. C</creatorcontrib><creatorcontrib>ROITT, I. M</creatorcontrib><creatorcontrib>COOKE, A</creatorcontrib><title>Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate.</description><subject>Animals</subject><subject>Autoantibodies - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Freund's Adjuvant</subject><subject>Haplotypes</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>Leukocyte Count</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Phenotype</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>T-Lymphocytes - immunology</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis, Autoimmune - genetics</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyroiditis, Autoimmune - pathology</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><recordid>eNqFkctKxDAUhoso4zj6CEIX4q6QS5s2LgQZvMGAG12X0ySdRtK0JqnQtzejw6ArIZCc_N_5OZejZIkpKzJCcn6cLBFCPOMY5afJmffvMWSMkUWyICznpMLLpF8rYyYDLtW21SY4CHqwMYhHTkLJNP6koZvdoKUO2t-kY6fsEOZRixQsmNlrHx8RVOY72Xd6TMOQbpVVIUJO-eC02EnnyUkLxquL_b1K3h7uX9dP2ebl8Xl9t8lGSnDIKBBBSQOMSFEwoRpJqoJIaFooUE4qhHmFcoA2523DWsUlp61kuCFFUTKS01Vy--M7Tk2vpFA2Nmbq0eke3FwPoOu_itVdvR0-a1zkuCpRNLjeG7jhY4oN1L32Io4KrBomX5dVVTHO6L8gLjDnvNyBl79LOtSy30TUr_Y6eAGmdWCF9gesJJiWiNMvJm-WvA</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>DE ASSIS-PAIVA, H. J</creator><creator>RAYNER, D. C</creator><creator>ROITT, I. 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Benign neoplasms</topic><topic>Phenotype</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>T-Lymphocytes - immunology</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis, Autoimmune - genetics</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyroiditis, Autoimmune - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE ASSIS-PAIVA, H. J</creatorcontrib><creatorcontrib>RAYNER, D. C</creatorcontrib><creatorcontrib>ROITT, I. 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M</au><au>COOKE, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1989</date><risdate>1989</risdate><volume>75</volume><issue>1</issue><spage>106</spage><epage>112</epage><pages>106-112</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>2649281</pmid><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9104 |
| ispartof | Clinical and experimental immunology, 1989, Vol.75 (1), p.106-112 |
| issn | 0009-9104 1365-2249 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1541870 |
| source | PubMed Central |
| subjects | Animals Autoantibodies - biosynthesis Biological and medical sciences Dose-Response Relationship, Immunologic Endocrinopathies Female Fluorescent Antibody Technique Freund's Adjuvant Haplotypes Histocompatibility Antigens Class II - genetics Leukocyte Count Macrophages - immunology Medical sciences Non tumoral diseases. Target tissue resistance. Benign neoplasms Phenotype Rats Rats, Inbred Strains T-Lymphocytes - immunology Thyroglobulin - immunology Thyroid Gland - pathology Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - genetics Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - pathology |
| title | Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction |
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