Interferon-gamma treatment increases HLA-DR expression on monocytes in severely injured patients

Traumatic injury and sepsis reduce HLA-DR expression on monocytes. This study assessed the effect of interferon-gamma (IFN-gamma) on the expression of HLA-DR on monocytes taken from severely injured patients. The mononuclear layer of each blood sample was incubated with either 500 units IFN-gamma or...

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Bibliographic Details
Published in:Clinical and experimental immunology 1989-07, Vol.77 (1), p.67-70
Main Authors: Hershman, M J, Appel, S H, Wellhausen, S R, Sonnenfeld, G, Polk, Jr, H C
Format: Article
Language:English
Subjects:
Cells, Cultured
HLA-DR Antigens - analysis
Humans
Interferon-gamma - pharmacology
Monocytes - drug effects
Monocytes - immunology
Space life sciences
Wounds and Injuries - immunology
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Summary:Traumatic injury and sepsis reduce HLA-DR expression on monocytes. This study assessed the effect of interferon-gamma (IFN-gamma) on the expression of HLA-DR on monocytes taken from severely injured patients. The mononuclear layer of each blood sample was incubated with either 500 units IFN-gamma or control media. The mean baseline HLA-DR expression of the trauma group (n = 11) was 32%, significantly less than the mean HLA-DR expression of 91% for the control group (n = 10). In the trauma group, HLA-DR expression after culturing with IFN-gamma was 81%, significantly greater than both the mean baseline HLA-DR expression (32%). In the control group, HLA-DR expression after culturing with IFN-gamma was 94%, similar to the mean baseline HLA-DR expression of 91%. These data confirm that HLA-DR on monocytes of severely injured patients is markedly reduced and show that it can be increased significantly in vitro by IFN-gamma.
ISSN:0009-9104
1365-2249