Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with reactive Yersinia arthritis

From synovial fluids of two patients with reactive arthritis following Yersinia enterocolitica infection, T lymphocyte clones were obtained that showed proliferative responses to Y. enterocolitica. The responses required autologous T-cell-depleted peripheral blood mononuclear cells as antigen presen...

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Bibliographic Details
Published in:Clinical and experimental immunology 1989-03, Vol.75 (3), p.365-370
Main Authors: HERMANN, E, FLEISCHER, B, MAYET, W. J, PORALLA, T, MEYER ZUM BÜSCHENFELDE, K.-H
Format: Article
Language:English
Subjects:
Adult
Antigens, Bacterial - immunology
Arthritis, Infectious - immunology
Bacterial arthritis and osteitis
Bacterial diseases
Biological and medical sciences
Clone Cells
Epitopes - immunology
Female
Human bacterial diseases
Humans
Infectious diseases
Knee Joint
Lymphocyte Activation
Male
Medical sciences
Synovial Fluid - immunology
T-Lymphocytes - immunology
Yersinia enterocolitica
Yersinia enterocolitica - immunology
Yersinia Infections - immunology
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Summary:From synovial fluids of two patients with reactive arthritis following Yersinia enterocolitica infection, T lymphocyte clones were obtained that showed proliferative responses to Y. enterocolitica. The responses required autologous T-cell-depleted peripheral blood mononuclear cells as antigen presenting cells. Three clones were studied in detail; two of them showed a marked and specific response to Yersinia antigens alone, the other one recognized both Yersinia and Salmonella typhimurium antigens. The antigen-specific proliferation of the clones could be completely blocked by monoclonal antibodies to HLA-DR. These experiments show that synovial T lymphocytes presumably involved in the in situ immune response to microbial antigens triggering reactive arthritis can be cloned directly from the site of inflammation.
ISSN:0009-9104
1365-2249