The CD4 Leu 8- T helper cell in colonic mucosa: a quantitative and functional analysis

CD4 T cells in the colonic lamina propria are primarily B cell helper as identified by their surface phenotype CD4 Leu 8- (CD4 Leu 8+:CD4 Leu 8- ratio = 1:3.5). This is in contrast to autologous peripheral blood where CD4 Leu 8+ cells predominate (CD4 Leu 8+:CD4 Leu 8- ratio = 2.4:1). Functionally C...

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Bibliographic Details
Published in:Clinical and experimental immunology 1989-02, Vol.75 (2), p.297-300
Main Authors: MING, R. H, STRICKLAND, R. G, LISTROM, M, FENOGLIO-PREISER, C
Format: Article
Language:English
Subjects:
Antigens, Differentiation - analysis
Antigens, Differentiation, T-Lymphocyte - analysis
B-Lymphocytes - immunology
Biological and medical sciences
Colon - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Immunoenzyme Techniques
Immunoglobulins - biosynthesis
Intestinal Mucosa - immunology
Lymphocyte Cooperation
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
T-Lymphocytes, Helper-Inducer - immunology
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Summary:CD4 T cells in the colonic lamina propria are primarily B cell helper as identified by their surface phenotype CD4 Leu 8- (CD4 Leu 8+:CD4 Leu 8- ratio = 1:3.5). This is in contrast to autologous peripheral blood where CD4 Leu 8+ cells predominate (CD4 Leu 8+:CD4 Leu 8- ratio = 2.4:1). Functionally CD4 Leu 8- T cells isolated from the colon are able to provide autologous peripheral blood B cell help comparable to that of peripheral blood CD4 Leu 8- T cells. Immunoperoxidase staining of colonic tissue sections confirmed the relative lack of Leu 8 staining cells in the lamina propria and that when present these cells are located in the outer margins of lymphoid follicles.
ISSN:0009-9104
1365-2249