Neutralizing antibody prevents type D retrovirus viremia in Celebes black macaques

The Celebes black macaque (Macaca nigra) colony at the Oregon Regional Primate Research Center has a high incidence of simian acquired immunodeficiency syndrome (SAIDS-RF) that may be caused by type D retrovirus type 2 (SRV-2). During the spring and autumn screening of the colony, seven monkeys prev...

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Bibliographic Details
Published in:Clinical and experimental immunology 1986-08, Vol.65 (2), p.265-268
Main Authors: WILSON, B. J, SHIIGI, S. M, ZEIGLER, J. L, OLSON, L. C, MALLEY, A, HOWARD, C. F
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - veterinary
AIDS/HIV
Animal viral diseases
Animals
Antibodies, Viral - analysis
Antibodies, Viral - immunology
Antigen-Antibody Complex - immunology
Biological and medical sciences
Infectious diseases
Macaca
Medical sciences
Monkey Diseases - immunology
Neutralization Tests
Retroviridae - immunology
Viral diseases
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Summary:The Celebes black macaque (Macaca nigra) colony at the Oregon Regional Primate Research Center has a high incidence of simian acquired immunodeficiency syndrome (SAIDS-RF) that may be caused by type D retrovirus type 2 (SRV-2). During the spring and autumn screening of the colony, seven monkeys previously aviremic were found to be viremic on the basis of the Raji co-culture assay. These monkeys and control groups were selected for further study, which included titration of neutralizing antibody activity and immunofluorescent antibody (IFA) activity before and at the time that the animals became viremic. Results indicated that neutralizing antibody was not present before or at the time that monkeys became viremic and that control monkeys who were IFA+ and did not become viremic had high levels of neutralizing antibody. The IFA titre did not change significantly or predictably at the time the animals became viremic.
ISSN:0009-9104
1365-2249