In situ characterization of T lymphocyte subpopulations in leprosy in the mangabey monkey

Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxid...

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Bibliographic Details
Published in:Clinical and experimental immunology 1986-08, Vol.65 (2), p.260-264
Main Authors: MODLIN, R. L, ORMEROD, L. D, WALSH, G. P, REA, T. H, MEYERS, W. M, BINFORD, C. H, MARTIN, L. N, WOLF, R. H, GORMUS, B. J
Format: Article
Language:English
Subjects:
Animals
Bacterial diseases
Biological and medical sciences
Cercopithecidae
Disease Models, Animal
Granuloma - etiology
Granuloma - immunology
Human bacterial diseases
Infectious diseases
Leprosy
Leprosy - complications
Leprosy - immunology
Male
Medical sciences
Skin - immunology
T-Lymphocytes - classification
Tropical bacterial diseases
Tropical medicine
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Summary:Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxidase technique. In both mangabey and human lepromatous granulomas OKT4 (or Leu 3a) and Leu 2a cells were scattered among macrophages with greater numbers of Leu 2a as compared with OKT4 (or Leu 3a) cells. The results suggest that from an immunopathological standpoint experimental leprosy in mangabeys will provide a suitable model for the investigation of the pathogenesis of human lepromatous leprosy and for the evaluation of new antileprosy vaccines.
ISSN:0009-9104
1365-2249