Aberrant expression of HLA-DR antigen on valvular fibroblasts from patients with active rheumatic carditis

Immunofluorescence and immunoperoxidase staining was used to investigate the expression of Class II major histocompatibility antigens in myocardial tissue of 16 patients with acute rheumatic carditis. Aberrant expression of HLA-DR was examined using monoclonal anti-Ia antibodies and was detected on...

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Bibliographic Details
Published in:Clinical and experimental immunology 1986-10, Vol.66 (1), p.88-94
Main Authors: AMOILS, B, MORRISON, R. C, WADEE, A. A, MARCUS, R, NININ, D, KING, P, SARELI, P, LEVIN, S, RABSON, A. R
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Bacterial diseases
Biological and medical sciences
Child
Female
Fibroblasts - immunology
Fluorescent Antibody Technique
Heart Valves - immunology
HLA-D Antigens - analysis
HLA-DR Antigens - analysis
Human bacterial diseases
Humans
Immunoenzyme Techniques
Infectious diseases
Male
Medical sciences
Mitral Valve - immunology
Myocarditis - immunology
Rheumatic Heart Disease - immunology
Staphylococcal infections, streptococcal infections, pneumococcal infections
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Summary:Immunofluorescence and immunoperoxidase staining was used to investigate the expression of Class II major histocompatibility antigens in myocardial tissue of 16 patients with acute rheumatic carditis. Aberrant expression of HLA-DR was examined using monoclonal anti-Ia antibodies and was detected on the valvular fibroblasts of those valves with ongoing active carditis. Sections of myocardial and valvular tissue from normal controls or from patients dying of other cardiac diseases did not express HLA-DR. The aberrant expression of HLA-DR on valvular fibroblasts could be important in triggering autoimmune destruction in that these cells could present self-antigens to sensitized T-lymphocytes which could initiate autoantibody production or direct destruction of local tissue.
ISSN:0009-9104
1365-2249