Chronic lymphoglandular enlargement and toxoplasmosis in children

Serum antitoxoplasma titres were determined simultaneously by the direct agglutination and the indirect immunofluorescent tests in 52 children aged 2 to 16 years having chronic lymph node enlargement, mainly cervical. Direct agglutination titres were raised (64 to 4096) in 22 children (42%), but rar...

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Bibliographic Details
Published in:Archives of disease in childhood 1977-05, Vol.52 (5), p.403-407
Main Authors: Thomaidis, T, Anastassea-Vlachou, K, Mandalenaki-Lambrou, C, Theodoridis, C, Vrahnou, E
Format: Article
Language:English
Subjects:
Adolescent
Agglutination Tests
Antibodies - analysis
Child
Child, Preschool
Fluorescent Antibody Technique
Humans
Lymphadenitis - etiology
Medical personnel
Toxoplasmosis
Toxoplasmosis - complications
Toxoplasmosis - diagnosis
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Summary:Serum antitoxoplasma titres were determined simultaneously by the direct agglutination and the indirect immunofluorescent tests in 52 children aged 2 to 16 years having chronic lymph node enlargement, mainly cervical. Direct agglutination titres were raised (64 to 4096) in 22 children (42%), but rarely in the control groups of children with acute suppurative lymphadenitis, and healthy children, adults, nurses, and physicians. It is concluded that toxoplasmosis is commoner in Greek children than previously believed, and that it should be included in the differential diagnosis of lymphoglandular enlargement. Clinically the condition is mild and may be self-limited, but it should be treated promptly with trimethoprim-sulphamethoxazole, in order to prevent reactivation in adult life.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.52.5.403