Cows' milk allergy in the syndrome of thrombocytopenia with absent radius

A girl with the syndrome of thrombocytopenia with absent radius had severe diarrhoea and dehydration relieved by withdrawal of cows' milk and aggravated by its reintroduction on three occasions. Deterioration in gastrointestinal symptoms was associated with haematological relapse with thrombocy...

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Bibliographic Details
Published in:Archives of disease in childhood 1976-05, Vol.51 (5), p.337-343
Main Authors: Whitfield, M F, Barr, D G
Format: Article
Language:English
Subjects:
Allergies
Animals
Cattle
Dehydration
Dehydration - etiology
Diarrhea, Infantile - etiology
Female
Food Hypersensitivity - blood
Food Hypersensitivity - complications
Food Hypersensitivity - diet therapy
Hematology
Humans
Infant
Infant, Newborn
Milk
Milk - adverse effects
Radius - abnormalities
Reintroduction
Thrombocytopenia - complications
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Summary:A girl with the syndrome of thrombocytopenia with absent radius had severe diarrhoea and dehydration relieved by withdrawal of cows' milk and aggravated by its reintroduction on three occasions. Deterioration in gastrointestinal symptoms was associated with haematological relapse with thrombocytopenia, leucocytosis, anaemia, and eosinophilia. There appeared to be a correlation between milk exposure and the haematological and gastrointestinal disturbances. Supporting evidence from published reports for such a correlation is reviewed. Cows' milk protein intolerance may be a factor in precipitating haematological relapse in susceptible infants with radius aplasia. Early withdrawal of cow's milk protein should be tried in thrombocytopenia with absent radius, especially in cases with prominent gastrointestinal upset.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.51.5.337