Serum thyrotrophin determination on day 5 of life as screening procedure for congenital hypothyroidism

In 327 newborns cord blood thyroxine (T4) was 11.8 +/- 0.4 mug/100 ml (SEM) (151.9 +/- 5.1 nmol/l), and serum thyrotrophin (TSH) 6.7+/-1.0 muU/ml. Variability was marked for both T4 and TSH. Remeasured in the same patients on the fifth day of life, the TSH level was 3.7 +/- 1.0 muU/ml, lower than at...

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Bibliographic Details
Published in:Archives of disease in childhood 1977-02, Vol.52 (2), p.89-96
Main Authors: Delange, F, Camus, M, Winkler, M, Dodion, J, Ermans, A M
Format: Article
Language:English
Subjects:
Congenital Hypothyroidism
Female
Fetal Blood - analysis
Humans
Hypothyroidism - blood
Hypothyroidism - diagnosis
Infant
Infant, Newborn
Male
Thyrotropin - blood
Thyroxine - blood
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Summary:In 327 newborns cord blood thyroxine (T4) was 11.8 +/- 0.4 mug/100 ml (SEM) (151.9 +/- 5.1 nmol/l), and serum thyrotrophin (TSH) 6.7+/-1.0 muU/ml. Variability was marked for both T4 and TSH. Remeasured in the same patients on the fifth day of life, the TSH level was 3.7 +/- 1.0 muU/ml, lower than at birth (P less than 0.001), while scattering of TSH values was much smaller, with 99.4 % of values less than 12 muU/ml...
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.52.2.89