Proximal gastric vagotomy versus long-term maintenance treatment with cimetidine for chronic duodenal ulcer: a prospective randomised trial

Forty-four patients with chronic duodenal ulceration were allocated randomly to either long-term maintenance treatment with cimetidine or proximal gastric vagotomy. All were followed up both clinically and endoscopically for periods of one to four years. The rate of recurrence of ulcer during and af...

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Bibliographic Details
Published in:BMJ 1983-01, Vol.286 (6359), p.98-99
Main Author: Gear, M W
Format: Article
Language:English
Subjects:
Cimetidine - adverse effects
Cimetidine - therapeutic use
Clinical Trials as Topic
Duodenal ulcer
Duodenal Ulcer - drug therapy
Duodenal Ulcer - surgery
Endoscopy
Female
Guanidines - therapeutic use
Herbs
Humans
Male
Middle Aged
Postoperative Complications
Pregnancy complications
Prospective Studies
Proximal gastric vagotomy
Random Allocation
Recurrence
Stomach ulcer
Surgical specialties
Symptoms
Ulcers
Vagotomy
Vagotomy, Proximal Gastric
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Description
Summary:Forty-four patients with chronic duodenal ulceration were allocated randomly to either long-term maintenance treatment with cimetidine or proximal gastric vagotomy. All were followed up both clinically and endoscopically for periods of one to four years. The rate of recurrence of ulcer during and after medical treatment was 54% while after surgery it was 10%. One patient developed severe allergic hepatitis while receiving maintenance treatment with cimetidine, and two others had to stop treatment because of possible drug reactions. Patients whose ulceration recurs while they are receiving treatment with cimetidine should be offered the possibility of operation.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.286.6359.98