Nocturnal hypoxia and prolactin secretion in obese women

Respiration during sleep was studied in six obese women who had impaired prolactin response to insulin induced hypoglycaemia (non-responders), six obese women with a normal prolactin response to hypoglycaemia (responders), and six lean women. Sleep apnoea did not occur in any subject. All the obese...

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Bibliographic Details
Published in:BMJ 1983-09, Vol.287 (6396), p.859-861
Main Authors: Kopelman, P G, Apps, M C, Cope, T, Empey, D W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Clinical Research
Eye movements
Female
Humans
Hypoxia
Hypoxia - etiology
Insulin
Insulin - pharmacology
Medical sciences
Metabolic diseases
Obesity
Obesity - complications
Oxygen
Oxygen - blood
Oxyhemoglobins - analysis
Prolactin - blood
Rapid eye movement sleep
Respiration
Respiratory Function Tests
Secretion
Sleep
Sleep, REM
Transponders
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Summary:Respiration during sleep was studied in six obese women who had impaired prolactin response to insulin induced hypoglycaemia (non-responders), six obese women with a normal prolactin response to hypoglycaemia (responders), and six lean women. Sleep apnoea did not occur in any subject. All the obese women showed a decrease in haemoglobin oxygen saturation when asleep, which occurred predominantly during periods of rapid eye movement sleep. That the fall in oxygen saturation was significantly greater (p less than 0.05) in the obese non-responders suggests that central as well as mechanical factors may be important for the genesis of nocturnal hypoxia and is evidence for a disturbance of central nervous function in some obese women.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.287.6396.859