Immunological abnormalities in haemophilia: are they caused by American factor VIII concentrate?

Scottish patients with haemophilia, most of whom had received no American factor VIII concentrate for over two years, were found to have immunological abnormalities similar to those in their American counterparts--that is, a reduced proportion of T helper cells, an increased proportion of T suppress...

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Bibliographic Details
Published in:BMJ 1983-10, Vol.287 (6399), p.1091-1093
Main Authors: Froebel, K S, Madhok, R, Forbes, C D, Lennie, S E, Lowe, G D, Sturrock, R D
Format: Article
Language:English
Subjects:
Adult
Aged
AIDS
Biological and medical sciences
Blood
Blood transfusion
Clinical Research
Concanavalin A - pharmacology
Cytomegalovirus
Factor VIII - therapeutic use
Hematologic and hematopoietic diseases
Hemophilia A
Hemophilia A - drug therapy
Hemophilia A - immunology
Humans
Immunity, Cellular
Immunology
Infections
Killer Cells, Natural
Leukocyte Count
Lymphocyte Activation
Lymphocytes
Male
Medical sciences
Middle Aged
Mitogens
Phytohemagglutinins - pharmacology
Platelet diseases and coagulopathies
Scotland
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes, Helper-Inducer
T-Lymphocytes, Regulatory
United States
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Summary:Scottish patients with haemophilia, most of whom had received no American factor VIII concentrate for over two years, were found to have immunological abnormalities similar to those in their American counterparts--that is, a reduced proportion of T helper cells, an increased proportion of T suppressor cells, and a reduced response to concanavilin A. Factor VIII from both the United States and Scotland severely inhibited the in vitro lymphocyte response to mitogens in patients and controls. The American and Scottish concentrates could not be distinguished in terms of either patient usage or their effect in vitro. These results argue against a disease vector specific to American blood products.
ISSN:0007-1447
0267-0623
0959-8138
1468-5833
DOI:10.1136/bmj.287.6399.1091