The effect of thyroid antigens on the in vitro migration of leucocytes from patients with Hashimoto thyroiditis

A total of fifty-two patients with Hashimoto thyroiditis were tested for delayed hypersensitivity to thyroid antigens using the leucocyte migration test. The percentage of patients showing abnormal migration in the presence of crude thyroid extract, thyroglobulin, thyroid mitochondria and thyroid mi...

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Bibliographic Details
Published in:Clinical and experimental immunology 1972-12, Vol.12 (4), p.429-438
Main Authors: Calder, E A, McLeman, D, Barnes, E W, Irvine, W J
Format: Article
Language:English
Subjects:
Antigens
Cell Migration Inhibition
Female
Fluorescent Antibody Technique
Humans
Kidney - immunology
Leukocytes - immunology
Male
Microsomes - immunology
Mitochondria - immunology
Mitochondria, Liver - immunology
Organ Specificity
Thyroglobulin
Thyroid Gland - immunology
Thyroiditis, Autoimmune - immunology
Tissue Extracts
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Summary:A total of fifty-two patients with Hashimoto thyroiditis were tested for delayed hypersensitivity to thyroid antigens using the leucocyte migration test. The percentage of patients showing abnormal migration in the presence of crude thyroid extract, thyroglobulin, thyroid mitochondria and thyroid microsomes was 75, 44, 54 and 34% respectively. Fifty-three control patients were studied concurrently with the same antigens and the percentage showing abnormal migration was 4, 6, 6 and 6% respectively. The antigenic activity of the mitochondrial fraction was not organ specific; both liver and kidney mitochondria interfered with the migration of leucocytes from patients with Hashimoto thyroiditis.
ISSN:0009-9104
1365-2249