Deficiency of the second component of complement associated with anaphylactoid purpura and presence of mycoplasma in the serum

A patient, with deficiency of the second component of complement (C2), who has had anaphylactoid purpura for 12 years is described. Other classical complement components were present normally and the very markedly low total haemolytic complement activity was restored by the addition of functionally...

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Bibliographic Details
Published in:Clinical and experimental immunology 1973-08, Vol.14 (4), p.531-539
Main Authors: Sussman, M, Jones, J H, Almeida, J D, Lachmann, P J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Blood - microbiology
Blood Coagulation Factors
Blood Platelets
Child
Complement System Proteins - analysis
Endotoxins - pharmacology
Female
Glycoproteins - blood
Humans
Immunologic Deficiency Syndromes - blood
Immunologic Deficiency Syndromes - complications
Immunologic Deficiency Syndromes - immunology
Immunologic Deficiency Syndromes - microbiology
Magnesium
Microscopy, Electron
Mycoplasma - isolation & purification
Mycoplasma Infections - complications
Phospholipids
Protein Binding
Purpura - blood
Purpura - complications
Purpura - immunology
Purpura - microbiology
Rabbits
Serratia marcescens
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Summary:A patient, with deficiency of the second component of complement (C2), who has had anaphylactoid purpura for 12 years is described. Other classical complement components were present normally and the very markedly low total haemolytic complement activity was restored by the addition of functionally purified C2. Glycine-rich β-glycoprotein (GBG), measured antigenically, was reduced to about 50% of normal but the alternate pathway to complement activation was normal as judged by the platelet factor three activation test. Structures identified morphologically as mycoplasma were present in the patient's serum.
ISSN:0009-9104
1365-2249