Inhibition of leucocyte migration as an index of rejection in renal transplant recipients

In a blind study, the peripheral blood leucocytes of fifteen recipients of cadaver kidney homografts have been checked at regular intervals for migration inhibition in the presence of antigen derived from donor spleen. Six of seven episodes of definite acute rejection were preceded or accompanied by...

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Bibliographic Details
Published in:Clinical and experimental immunology 1973-09, Vol.15 (1), p.17-25
Main Authors: Richmond, D E, Doak, P B, North, J D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Azathioprine - therapeutic use
Cell Migration Inhibition
Creatinine - urine
Female
Graft Rejection
Humans
Kidney Transplantation
Leukocytes - immunology
Male
Middle Aged
Postoperative Complications - diagnosis
Prednisone - therapeutic use
Spleen - immunology
Time Factors
Transplantation, Homologous
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Summary:In a blind study, the peripheral blood leucocytes of fifteen recipients of cadaver kidney homografts have been checked at regular intervals for migration inhibition in the presence of antigen derived from donor spleen. Six of seven episodes of definite acute rejection were preceded or accompanied by migration inhibition, and four of seven probable acute rejection crisis were similarly accompanied by inhibition. No false positive tests were observed. The technique may be a useful adjunct to present methods of diagnosing acute homograft rejection.
ISSN:0009-9104
1365-2249