Purification and properties of a lymphocyte inhibition factor from human serum

Recognition of antigen by sensitized human lymphocytes can be demonstrated by cell electrophoresis. A serum factor able to block this recognition was found to be associated with the alpha-2 macroglobulin (α 2 M) protein. The factor was heat labile, susceptible to certain proteases and produced an ac...

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Bibliographic Details
Published in:Clinical and experimental immunology 1973-10, Vol.15 (2), p.169-179
Main Authors: Ford, W H, Caspary, E A, Shenton, B
Format: Article
Language:English
Subjects:
Animals
Cell Migration Inhibition
Centrifugation
Chemical Precipitation
Clinical Enzyme Tests
Electrophoresis
Guinea Pigs - immunology
Hot Temperature
Humans
Immune Sera - isolation & purification
Immunoelectrophoresis
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunosuppression
Lymphocytes - immunology
Macroglobulins
Macrophages - immunology
Molecular Weight
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Summary:Recognition of antigen by sensitized human lymphocytes can be demonstrated by cell electrophoresis. A serum factor able to block this recognition was found to be associated with the alpha-2 macroglobulin (α 2 M) protein. The factor was heat labile, susceptible to certain proteases and produced an active low molecular weight component when treated with sulphydryl reagents. It appeared to act directly on the lymphocyte, preventing response to subsequently encountered antigen.
ISSN:0009-9104
1365-2249