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Inhibition of autoimmune diabetes in NOD mice with serum from streptococcal preparation (OK‐432)‐injected mice

SUMMARY We have recently reported that systemic and chronic administration of recombinant tumour necrosis factor alpha (TNF‐α), as well as streptococcal preparation (OK‐432), inhibits development of insulin‐dependent diabetes mellitus (IDDM) in NOD mice and BB rats, models of IDDM. In this study we...

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Published in:Clinical and experimental immunology 1991-12, Vol.86 (3), p.413-418
Main Authors: SEINO, H., SATOH, J., SHINTANI, S., TAKAHASHI, K., ZHU, X. P., MASUDA, T., NOBUNAGA, T., SAITO, M., TERANO, Y., TOYOTA, T.
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Language:English
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Summary:SUMMARY We have recently reported that systemic and chronic administration of recombinant tumour necrosis factor alpha (TNF‐α), as well as streptococcal preparation (OK‐432), inhibits development of insulin‐dependent diabetes mellitus (IDDM) in NOD mice and BB rats, models of IDDM. In this study we examined whether serum containing endogenous TNF induced by OK‐432 injection could inhibit IDDM in NOD mice. Treatment twice a week from 4 weeks of age with OK‐432‐injected mouse serum, which contained endogenous TNF (75U), but not IL‐1, IL‐2 and interferon‐gamma (IFN‐γ) activity, reduced the intensity of insulitis and significantly inhibited the cumulative incidence of diabetes by 28 weeks of age in NOD mice, as compared with the incidence in non‐treated mice (P
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1991.tb02946.x