The life situations of patients with primary antibody deficiency untreated or treated with subcutaneous gammaglobulin infusions

SUMMARY The life situations of 25 patients with hypogammaglobulinaemia were studied before and after the initiation of subcutaneous replacement therapy by using medical records, data registers and questionnaires (a study and a disease‐specific questionnaire, the Sickness Impaet Profile and the Gener...

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Bibliographic Details
Published in:Clinical and experimental immunology 1993-05, Vol.92 (2), p.200-204
Main Authors: GARDULF, A., BJORVELL, H., GUSTAFSON, R., ARSTRÖM, L. H AMM, SMITH, C. I. E.
Format: Article
Language:English
Subjects:
Adult
Agammaglobulinemia - complications
Agammaglobulinemia - physiopathology
Agammaglobulinemia - therapy
Aged
Biological and medical sciences
Communicable Disease Control
Female
gamma-Globulins - therapeutic use
gammaglobulin treatment
health
Health Status Indicators
Humans
hypogammaglobulinaemia
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulinopathies
Immunoglobulins - metabolism
Immunopathology
Injections, Subcutaneous
Male
Medical sciences
Middle Aged
Quality of Life
Surveys and Questionnaires
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Summary:SUMMARY The life situations of 25 patients with hypogammaglobulinaemia were studied before and after the initiation of subcutaneous replacement therapy by using medical records, data registers and questionnaires (a study and a disease‐specific questionnaire, the Sickness Impaet Profile and the General Health Rating Index). Before treatment, the patients perceived more dysfunctions with regard to ambulation. mobility, emotional behaviour, social interaction, sleep and rest, household management, work and recreation or pastime activities compared with a Swedish reference group (P= 0.0001). A significant increase in the perceived frequency of infections was also seen in untreated patients compared with a group of healthy individuals (P=0.0001) After 18 months of weekly subcutaneous infusions of an intramuscular gammaglobulin preparation (100 mg/kg), the patients reported a significantly increased, health‐related function and improved self‐rated health. A significantly higher pre‐infusion IgG level was also found.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.1993.tb03380.x