Regulation of immune responses against the syngeneic ADJ-PC-5 plasmacytoma in BALB/c mice. I. Analysis of immune parameters involved

The non-secreting variant of ADJ-PC-5 plasma cell tumour of BALB/c mice is a highly malignant tumor, the LD50 being 3 x 10(1) cells/mouse after intraperitoneal injection. Nevertheless, immunization against the tumour is possible. Four injections of 10(7) X-irradiated tumour cells at weekly intervals...

Full description

Saved in:
Bibliographic Details
Published in:Immunology 1981-05, Vol.43 (1), p.133-143
Main Authors: Cihak, J, Ziegler, H W, Kölsch, E
Format: Article
Language:English
Subjects:
Animals
Antibodies, Neoplasm - biosynthesis
Antibody-Dependent Cell Cytotoxicity
Antigens, Surface - immunology
Antigens, Viral - immunology
Cells, Cultured
Cytotoxicity, Immunologic
Female
Immunity, Cellular
Immunization, Passive
Leukemia Virus, Murine - immunology
Male
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental - immunology
Plasmacytoma - immunology
Transplantation, Isogeneic
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The non-secreting variant of ADJ-PC-5 plasma cell tumour of BALB/c mice is a highly malignant tumor, the LD50 being 3 x 10(1) cells/mouse after intraperitoneal injection. Nevertheless, immunization against the tumour is possible. Four injections of 10(7) X-irradiated tumour cells at weekly intervals render up to 95% of mice resistant to an otherwise lethal challenge with 10(3) living tumour cells. The immune responses are both T cell-mediated cellular cytotoxicity and antibody-mediated cytotoxicity as assessed by in vitro tests. Immunity can also be transferred in vivo into recipient mice by either spleen cells or immune sera. Specificity of both types of immune responses was determined. The results indicate that the cell-mediated and the humoral immune response are directed against cell-surface antigens associated with endogenous murine leukemia virus.
ISSN:0019-2805
1365-2567