Normal Histology of the Nasal Cavity and Application of Special Techniques

There are three major epithelial types in the nasal mucosa, in addition to numerous accessory structures, some of which are species specific. Without careful and consistent processing of the nose tissue, histopathologic assessment of lesions in the nasal cavity may be compromised. While formalin fix...

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Bibliographic Details
Published in:Environmental health perspectives 1990-04, Vol.85, p.187-208
Main Authors: Uraih, Linda C., Maronpot, R. R.
Format: Article
Language:English
Subjects:
Acetates
Acetic Acid
Animals
Basement membrane
Decalcification Technique
Epithelial cells
Epithelium
Epithelium - anatomy & histology
Epithelium - ultrastructure
Fixatives
Formaldehyde
Histological Techniques
Histology
Male
Microscopy, Electron
Mucosa
Nasal cavity
Nasal Cavity - anatomy & histology
Nasal Cavity - ultrastructure
Nasal Mucosa - anatomy & histology
Nasal Mucosa - ultrastructure
Neurons
Nose
Picrates
Rats
Rats, Inbred F344
Symposium on Toxicologic Pathology of the Upper Respiratory System. September 14-16, 1988. Durham, North Carolina
Teeth
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Summary:There are three major epithelial types in the nasal mucosa, in addition to numerous accessory structures, some of which are species specific. Without careful and consistent processing of the nose tissue, histopathologic assessment of lesions in the nasal cavity may be compromised. While formalin fixation may be used for routine review of the nasal cavity, Bouin's fixation provides better histologic detail and fewer artifacts. Decalcification is not recommended for nasal tissues to be examined by transmission electron microscopy because of the detrimental effect of decalcifying solutions on sensory cells. Three levels of the nasal cavity may be used for routine histologic review of the nasal cavity, but four or five levels may be more appropriate for certain studies.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.85-1568325