The Role of Toxicological Interactions in Lung Injury

Interactions between two or more toxic agents can produce lung damage by chemical-chemical interactions, chemical-receptor interactions or by modification, by a first agent, of the cell and tissue response to a second agent. Interactions may occur by simultaneous exposure and if exposure to the two...

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Bibliographic Details
Published in:Environmental health perspectives 1984-04, Vol.55, p.139-148
Main Authors: Witschi, H. P., Hakkinen, P. J.
Format: Article
Language:English
Subjects:
Aerosols
Air Pollutants - toxicity
Animals
Binding, Competitive
Chemical hazards
Dosage
Drug Interactions
Enzyme Induction - drug effects
Free Radicals
Humans
Lung Diseases - chemically induced
Lung injury
Lungs
Metabolism
Mixed Function Oxygenases - metabolism
Monograph on Pulmonary Toxicology
Oxygen
Oxygen - toxicity
Subcellular Fractions - metabolism
Superoxides
Time Factors
Toxicity
Toxicology
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Summary:Interactions between two or more toxic agents can produce lung damage by chemical-chemical interactions, chemical-receptor interactions or by modification, by a first agent, of the cell and tissue response to a second agent. Interactions may occur by simultaneous exposure and if exposure to the two agents is separated in time. Chemical-chemical interactions have been mostly studied in the toxicology of air pollutants, where it was shown that the untoward effect of certain oxidants may be enhanced in the presence of other aerosols. Interactions at the receptor site have been found in isolated perfused lung experiments. Oxygen tolerance may be an example, when pre-exposure to one concentration of oxygen mitigates later exposure to 100% oxygen by modifying cellular and enzymatic composition of the lung. Damage of the alveolar zone by the antioxidant butylated hydroxytoluene (BHT) can be greatly enhanced by subsequent exposure to oxygen concentration which, otherwise, would have little if any demonstrable effect. The synergistic interaction between BHT and oxygen results in a resulting interstitial pulmonary fibrosis. Acute or chronic lung disease may then be caused not only by one agent, but very likely in many instances by the interaction of several agents.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.8455139