Pneumoconiosis in animals exposed to poly(vinyl chloride) dust

Rats, guinea pigs and monkeys were exposed by inhalation (6 hr/day, 5 days/week) for up to 22 months to a 13 mg/ m3concentration of PVC dust. Autopsies on rats and guinea pigs were performed after 12 months of exposure and on monkeys after 22 months of exposure. Lung function tests were performed on...

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Bibliographic Details
Published in:Environmental health perspectives 1981-10, Vol.41, p.73-81
Main Authors: Groth, D.H, Lynch, D.W, Moorman, W.J, Stettler, L.E, Lewis, T.R, Wagner, W.D, Kommineni, C
Format: Article
Language:English
Subjects:
Animals
Cell aggregates
Chlorides
Conference to Reevaluate the Toxicity of Vinyl Chloride Monomer, Poly(vinyl Chloride) and Structural Analogs. National Institutes of Health, Bethesda, MD. March 20-21, 1980
Dust
Guinea Pigs
Haplorhini
Lung - pathology
Lungs
Macrophages
Macrophages - ultrastructure
Male
Microscopy, Electron, Scanning
Pneumoconiosis - etiology
Pneumoconiosis - pathology
Polyvinyl Chloride - administration & dosage
Polyvinyl Chloride - analysis
Polyvinyl Chloride - toxicity
Polyvinyls - toxicity
Pulmonary functions
Rats
Rats, Inbred Strains
Rodents
Vinyl polymers
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Summary:Rats, guinea pigs and monkeys were exposed by inhalation (6 hr/day, 5 days/week) for up to 22 months to a 13 mg/ m3concentration of PVC dust. Autopsies on rats and guinea pigs were performed after 12 months of exposure and on monkeys after 22 months of exposure. Lung function tests were performed on monkeys after 9, 14 and 22 months of exposure. Aggregates of alveolar macrophages containing PVC particles were found in the lungs of all animals. These aggregates were more numerous in the monkey lungs. No fibrosis or significant cellular infiltrates were present in or near these cellular aggregates. No significant effects on pulmonary function could be demonstrated in the monkeys exposed to PVC. Under the conditions of this experiment, inhaled PVC produced a benign pneumoconiosis.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.814173