Factors Involved in the Cytotoxicity of Kaolinite towards Macrophages in Vitro

The cytotoxicity of a high purity Cornish kaolinite toward mouse peritoneal macrophages in vitro was examined. The material was cytotoxic towards these cells, the activity could be decreased substantially by pretreating the dust with poly(2-vinylpyridine N-oxide). Pretreatment of the dusts with poly...

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Bibliographic Details
Published in:Environmental health perspectives 1983-09, Vol.51, p.249-252
Main Author: Davies, Reginald
Format: Article
Language:English
Subjects:
Acrylic Resins - pharmacology
Animals
Cell Survival - drug effects
Cells, Cultured
Cytotoxicity
Dust - adverse effects
Enzymes
Female
Kaolin - toxicity
Kaolinite
L-Lactate Dehydrogenase - metabolism
Lactates
Macrophages
Macrophages - drug effects
Magnetite
Mice
Minerals
Peritoneal macrophages
Pneumoconiosis
Polymers
Polyvinylpyridine N-Oxide - pharmacology
The Second International Workshop on in Vitro Effects of Mineral Dusts. April 25-28, 1982. Arkadelphia, Arkansas
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Summary:The cytotoxicity of a high purity Cornish kaolinite toward mouse peritoneal macrophages in vitro was examined. The material was cytotoxic towards these cells, the activity could be decreased substantially by pretreating the dust with poly(2-vinylpyridine N-oxide). Pretreatment of the dusts with poly(acrylic acid) had a small effect on cytotoxicity, but combinations of the polymer treatments virtually abolished the material's biological activity towards macrophages. These studies indicated that the cytotoxicity of kaolinite is not due to its flakelike morphology.
ISSN:0091-6765
1552-9924
DOI:10.1289/ehp.8351249