The influence of allopurinol on kidney haemodynamic and excretory responses to renal ischaemia in anaesthetized rats

This study examined the impact of allopurinol on the renal functional responses to a 30 min period of ischaemia in anaesthetized rats. Immediately on reperfusion, blood pressure rose transiently, while renal blood flow remained stable throughout at control values. Glomerular filtration rate was decr...

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Bibliographic Details
Published in:British journal of pharmacology 1999-09, Vol.128 (1), p.255-261
Main Authors: Hestin, Dominique, Johns, Edward J
Format: Article
Language:English
Subjects:
Acute Disease
Allopurinol - pharmacology
Anesthesia
Animals
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Disease Models, Animal
glomerular filtration rate
Glomerular Filtration Rate - drug effects
Ischemia - blood
Ischemia - enzymology
Ischemia - physiopathology
Ischemia - urine
Kidney - blood supply
Kidney - drug effects
Kidney - metabolism
Kidney - physiopathology
Male
Medical sciences
Pharmacology. Drug treatments
Potassium - urine
Rats
Rats, Wistar
Renal Artery - injuries
Renal blood flow
Renal Circulation - drug effects
renal ischaemia
Reperfusion Injury - blood
Reperfusion Injury - enzymology
Reperfusion Injury - physiopathology
Reperfusion Injury - urine
Sodium - urine
sodium excretion
Time Factors
Vascular wall
xanthine oxidase
Xanthine Oxidase - antagonists & inhibitors
Xanthine Oxidase - metabolism
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Summary:This study examined the impact of allopurinol on the renal functional responses to a 30 min period of ischaemia in anaesthetized rats. Immediately on reperfusion, blood pressure rose transiently, while renal blood flow remained stable throughout at control values. Glomerular filtration rate was decreased by some 90% over the first and 80% over the sixth hour (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0702789